Hydrogel loaded with nanostructures based on superparamag-netic particles and hydroxyapatites for local delivery of anti-fungal and anti-inflammable drugs
Abstract
Hydrogels are widely used in medicine due to their facile loading with many different biologi-cally active molecules and easy synthesis. They offer prolonged and spatial control for releasing different therapeutic agents in different various tissues. In our study, we focused on the prepa-ration of hydrogels as drug carriers for the treatment of wounds, including gum disease lesions. The proposed hydrogel loaded with hydroxyapatite and superparamagnetic iron oxide nanopar-ticles (SPIONs) was proposed to be a novel way to deliver anti-inflammatory and antifungal drugs. The nanoparticles were synthesized using a co-precipitation technique and incorporated into the hydrogel before being cross-linked together with anti-inflammatory and antifungal drugs. The hydrogel can be designed in a specific shape and size and can be 3D printed, making it a prom-ising material for dental applications, offering prolonged drug release, biocompatibility and the ability to carry different therapeutic agents. Drug release was studied by UV-vis spectrometry. The effectiveness of heating the hydrogel with SPION was investigated using magnetic hyperther-mia. It was found that by loading SPIONs into the polymeric network of hydrogel, it was possible to increase the gel temperature up to 42 °C by means of an alternating magnetic field while im-proving drug release, while the loading of hydroxyapatites enables prolonged drug release.
Paulina Pietrzyk-Thel
Organising Committee Member
Magdalena Osial
Conference co-Chair
