Antimicrobial Coordination Polymers: From Self-Assembly to Biomaterials


To address increasing antimicrobial resistance, the search for new bioactive molecules and sus-tainable materials is currently in high demand. This presentation will highlight our recent research on the self-assembly synthesis, crystallization methods, structural features and applications of a wide diversity of functional metal-organic architectures, including bioactive metal-organic frameworks (MOFs), coordination polymers (CPs), metal complexes and derived materials with potent antibacte-rial and biofilm inhibition properties. The following topics will be discussed. (A) Self-assembly generation and structural diversity of silver(I) and copper(II) coordination pol-ymers derived from carboxylic acids, aminoalcohols and other ligands. (B) Application of these compounds as efficient antimicrobials against different types of Gram-positive and Gram-negative bacteria, bacterial biofilms, and fungi. (C) Design of CP-doped biopolymer films based on soybean oil, potato starch, agarose or cellu-lose. (D) Antibacterial and biofilm inhibition activity of the obtained biopolymer films as a function of dopant type and loading, biopolymer matrix, and metal ion release rates. This multidisciplinary study expands the antimicrobial use of bioactive coordination polymers and hybrid biopolymer materials obtained from renewable and low-cost biofeedstock sources.

2nd International Conference on Advanced Materials for Bio-Related Applications