Synthesis of Mn-doped TiO₂ Nanoparticles
Abstract
The usability of metal oxide nanoparticles has expanded into new fields over the past decade. Particular attention has been focused on biocompatible metal oxides in medical applications including encapsulation of cells. Titanium and manganese oxides are very valuable in this aspect, however, their combined properties have not been fully investigated. The application of NP in medicine has high demands both in enhancing natural processes such as wound healing and in enabling imaging of the treated regions. In this study, we aimed to produce Mn-doped TiO2 nanoparticles as potentially highly biocompatible nanozymes, applying solvothermal synthesis and a novel hydrothermal method. In both approaches, nanoparticles differing in crystallite size, oxidation-reduction potential, solubility and photocatalytic properties were obtained. Pre-functionalized polyanionic polystyrene nanospheres were used to demonstrate the ap-plicability of nanoparticles for model encapsulation. The Mn-doped TiO2 nanoparticles effectively encapsulated them, simultaneously revealing differences in the encapsulation process. Further encapsulation of human cells showed similar biocompatibility and high cell viability in vitro for both types of materials.
Gulaim A. Seisenbaeva
Scientific Committee Member
