Porous magnetic nanostructures for sensing SARS-CoV-2
Abstract
The intelligent engineering of nanostructures by means of appropriate surface or bulk function-alization will endow them with multi-functional capabilities, opening new opportunities in the bio-medical field such as biosensing, drug delivery, imaging, medical implants, cancer treatment and tissue engineering. Here we demonstrate a cost-effective design approach for preparing nanostructures that show effective potential in rapid detection of SARS-CoV-2, based on the sur-face-enhanced Raman scattering (SERS) as well as power source for implanted medical devices. The three-dimensional (3D) porous nanoplatform with plasmonic-active nanostructures provides a high sensitivity for the detection of the virus by means of the remarkable SERS signal collection. The outstanding sensitivity of our SERS biosensor was demonstrated with SARS-CoV-2 at the detection limit of 1 fg mL-1 and 0.1 pg mL-1, respectively. Our work demonstrates a low-cost de-sign approach for targeted functional nanoplatform with potential for applications in biosensing and bioelectronics.
