Intensive research are currently underway to unearth novel luminescent materials pos-sessing desirable characteristics tailored for medical applications, particularly as theranostic agents for therapeutic interventions and bioimaging [1], [2]. In this aim, a pioneering ap-proach involved the fabrication of single-phase calcium chlorapatite (Ca10(PO4)6Cl2, abbrevi-ated as CaClAp) phosphors, activated with varied concentrations of Ce3+ ions. These phos-phors were successfully synthesized via hydrothermal method with the goal of investigating how varying dopant concentration affect the physicochemical attributes of the materials. The investigation encompassed an exploration of the structural modifications, photolumi-nescence (PL) behavior, energy transfer phenomena, substitution site preferences, and fluo-rescence lifetime.